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MolQ

9999778778

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MQONCO004

BCL-6 by FISH

Specimen: Tumor FFPE block

Method: Fluorescence in situ hybridization (FISH)

Temperature Requirement: Ambient temperature

Reported on: 810 Working Days

General Instructions: Please provide a copy of the pathology report

BCL-6 (B-cell lymphoma 6) is a gene associated with the development of various lymphomas, especially B-cell non-Hodgkin lymphomas (NHL). Abnormalities in the BCL-6 gene, such as translocations or gene rearrangements, are often observed in these lymphomas. Fluorescence In Situ Hybridization (FISH) is a molecular technique used to detect and assess BCL-6 gene abnormalities in cancer cells. Here’s how BCL-6 testing by FISH works:

  • Sample Collection: A tissue sample, typically obtained through a biopsy or surgical procedure, is collected from the patient. This tissue sample contains lymphoma cells.
  • Tissue Preparation: The collected tissue sample is processed and prepared for FISH analysis. This may involve fixing the tissue and preparing thin sections on glass slides.
  • FISH Probe Preparation: Specific DNA probes are designed to target the BCL-6 gene region. These probes are labeled with fluorescent molecules that emit distinct colors when exposed to specific wavelengths of light.
  • Hybridization: The tissue sample is incubated with the DNA probes. If there are abnormalities in the BCL-6 gene, such as translocations or rearrangements, the DNA probes will bind to the corresponding target sequences.
  • Fluorescent Labeling: When the DNA probes bind to the target BCL-6 gene sequences, they emit fluorescent signals. These signals can be visualized and analyzed using a fluorescent microscope.

Imaging and Analysis: The tissue sample is examined under the fluorescent microscope. The number and pattern of fluorescent signals are assessed. Abnormalities, such as BCL-6 gene translocation or rearrangement, are identified based on the presence of altered patterns of fluorescence signals.

The results of BCL-6 FISH testing provide valuable information about the genetic characteristics of lymphoma cells. These results can help guide treatment decisions, including the selection of specific therapies or the assessment of the lymphoma’s aggressiveness.

Frequently Asked Questions

What types of tests does the laboratory offer?

The laboratory provides a range of tests across various disciplines including [mention specific areas, e.g., chemistry, microbiology, genetics, etc.].

For more details go to the Laboratory Section

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The frequency of health checkups depends on factors such as age, gender, family history, and existing health conditions. Consult with MolQ Laboratory’s customer care executive to determine an appropriate schedule.

What should I expect during a health checkup?

A health checkup typically includes a physical examination, measurements of vital signs, blood tests, and other screenings based on individual health needs. MolQ Laboratory's customer care executive will discuss the specific components with you.

Do I need to fast before a health checkup?

Some blood tests require fasting for accurate results. MolQ Laboratory’s customer care executive will inform you if fasting is necessary and provide specific instructions on the duration and other details.

How long does it take to get results?

The turnaround time for test results varies depending on the type of test. Routine tests may have quicker results, while more complex or specialized tests may take longer. MolQ Laboratory's customer care executive will inform you about the expected timeline. For queries and concerns call 9999778778.

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Laboratories adhere to strict privacy and confidentiality regulations. Your personal health information is handled securely, and access is restricted to authorized personnel only.

How Can I make payment for test booking?

You can pay for your tests through net banking, debit card, credit card, UPI, or COD. Once you have made the booking you will see your order and booking summary on the app & and website and will also receive an SMS with details of your booking and sample collection slot on your registered mobile number.


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